ACS South Texas Local Section
February Meeting at UTRGV Edinburg
February 9, 2018, ESCNE 2.102 directions
Social: 6:00 pm-7:00 pm Lecture: 7:00 pm-8:00 pm
The Biochemistry of Glutathione
A Hundred Year Old Mystery
Dr. Mary Anderson (Texas Woman’s University)
Dr. Thomas R. Cundari (University of North Texas)
Abstract: Glutathione is arguably the body’s most important anti-oxidant. It is a tri-peptide that is biosynthesized by two enzymes, one of which is glutathione synthetase (GS). GS is a rare, but growing in both number of examples and importance – example of a negatively cooperative protein. In the case of GS, cooperativity implies communication between catalytic active sites separated by ~ 50 Å!
This level of active site communication in enzymes is essentially unheard of in inorganic catalysts. Since the discovery of protein cooperativity by Bohr more than 100 years ago, there has been considerable controversy as to the mechanism of protein cooperativity at the atomic level. Through a combination of modeling, informatics, structural analysis, and kinetics experiments we seek to understand the pathway(s) for communication between active sites at such great distances in biological catalysts.
Dr. Mary Anderson
Born in San Antonio Texas. Undergraduate at Hollins University (Roanoke,
VA). PhD at Cornell University Graduate School of Medicine Sciences. Rose
through the ranks @ Cornell, sabbatical @ Panum Institute in Copenhagen,
Denmark. Faculty @ University of Memphis. Moved back to Texas in 2002,
faculty, Department of Chemistry and Biochemistry, Texas Woman’s
University. Currently Associate Professor. Former President of local ACS-DFW
section, currently councilor.
Dr. Thomas R. Cundari
Born in Brooklyn, New York. Undergraduate at Pace University (NYC). PhD at
University of Florida. Postdoc: North Dakota State University. Rose through the
ranks @ University of Memphis. Moved to Texas in 2002, faculty, Department
of Chemistry, University of North Texas. Currently Regents Professor of
Chemistry. Currently councilor for ACS Division of Inorganic Chemistry